Psychological Morbidities and Health-Related Quality of Life in Adolescents with Celiac Disease

Abstract

Background: Celiac disease (CD) is a chronic autoimmune condition triggered by
gluten ingestion, with significant implications on both physical and psychological
well-being. Adolescents with CD may experience psychological morbidities that
adversely affect their health-related quality of life (HRQoL).
Objective: To evaluate the prevalence and types of psychological morbidities and
assess their impact on health-related quality of life among adolescents with celiac
disease.
Methods: A cross-sectional observational study was conducted among 100
adolescents diagnosed with CD aged between 10 and 18 years. Psychological
morbidities, including anxiety and depression, were assessed using standardized
questionnaires (Pediatric Symptom Checklist, Pediatric Quality of Life Inventory).
HRQoL was evaluated using the Pediatric Quality of Life Inventory (PedsQL)
Generic Core Scales. Scores were analyzed and correlated with clinical variables.
Results: The prevalence of psychological morbidities was high, with anxiety
identified in 38% and depression in 24% of adolescents. Adolescents experiencing
psychological morbidities showed significantly lower HRQoL scores across physical,
emotional, social, and school functioning domains (p < 0.001). Dietary adherence
was positively correlated with better HRQoL and fewer psychological symptoms.
Conclusion: Adolescents with celiac disease have a high prevalence of psychological
morbidities, significantly impacting their health-related quality of life. Regular
psychological screening and supportive interventions should be integrated into
routine clinical care for improving overall patient outcomes.