STUDY OF ASSOCIATION OF MEAN PLATELET VOLUME IN PATIENTS WITH DIABETIC NEPHROPATHY

Abstract

Background: Diabetic nephropathy (DN) is a significant microvascular
complication of diabetes mellitus, contributing to chronic kidney disease (CKD) and
cardiovascular risk. Mean platelet volume (MPV) has emerged as a potential
biomarker of thrombotic and inflammatory activity.
Objective: To investigate the association between MPV and diabetic nephropathy.
Methods: A hospital-based cross-sectional study was conducted among 59 patients
with type 2 diabetes mellitus and microalbuminuria. Clinical parameters including
MPV, glycemic control indices, renal function markers, and comorbid conditions
were assessed.
Results: Mean age was 61.7 ± 8.4 years with a male predominance (64.4%). The
mean MPV was 11.1 ± 1.2 fL. Higher MPV values were associated with increased
albuminuria, lower GFR, and thrombotic events. There was a positive correlation
between MPV and severity of diabetic nephropathy.
Conclusion: Elevated MPV is significantly associated with DN and may serve as an
adjunctive marker for disease severity and cardiovascular risk stratification. Routine
MPV monitoring could aid in early identification of high-risk patients.