THE EFFECT OF HBA1C LEVEL ON KEDNEY FUNCTION IN PATIENT WITH TYPE 2 DIABETES MELLITUS

Abstract

Diabetes is one of the most common endocrine disorders characterized by
hyperglycaemia. Diabetic nephropathy is a consequence of long standing diabetes.
The prevalence of microalbuminuria predicts progression to diabetic nephropathy.
The present study was conducted to determine the prevalence of microalbuminuria in
relation to HbA1c in Diabetic cases in comparison to healthy controls.
Objective of the study: Lots of studies have been conducted on the levels of
microalbumin and HbA1c in a patient with diabetes mellitus. Since the role of these
parameters are increasingly reviewed and evaluated, the need to carry out further
such studies become obvious. The present study is thus designed to evaluate the role
of microalbumin and glycated haemoglobin in predicting incipient nephropathy in
diabetics so as to prevent the onset of overt nephropathy
Materials and Methods: This case-control descriptive study was conducted on One
hundred known diabetic patients with age 21–90 years were included in the study.
Informed consent and a structured questionnaire of each patient were recorded.
Fasting venous blood and morning urine sample was collected for analysis of Fasting
blood glucose, HbA1c and urinary microalbumin respectively. Statistical analysis
was done using graph stat statistical software.
All p-values <0.05 were considered as statistically significant.
Results: Fasting blood glucose levels , urinary microalbumin, and blood HbA1C
levels were very high in diabetic cases as compared to healthy controls ( p- value
0.0). Also the urinary microalbumin levels were very high in the diabetic cases with
poor glycaemic control.
Conclusion: The present study found higher level of HbA1C and urinary
microalbumin level in diabetics. Also high level of microalbuminuria in the cases
which could be due to poor glycaemic control (high HbA1C >7%). Screening for
microalbuminuria and HbA1c test should be done in both newly and already
diagnosed diabetic patients as an early marker of renal dysfunction and glycaemic
control.