EVALUATION OF OXIDATIVE STRESS AND ANTI OXIDANT STATUS IN CHRONIC KIDNEY DISEAS

Abstract

Background: Chronic Kidney Disease (CKD) is a progressive condition characterized by a gradual loss of renal function, often associated with increased oxidative stress and impaired antioxidant defence. Oxidative stress plays a critical role in the pathophysiology and progression of CKD and its complications, particularly cardiovascular disease.
Objective: To estimate the concentrations of MDA (Malondialdehyde), a product of lipid peroxidation and to describe their relationship with several pathophysiologic processes in cases of chronic kidney disease and their possible therapeutic implications, in improving the renal parameters.
Methods: A case-control study was conducted involving CKD patients at various stages and age-matched healthy controls. Blood samples were analysed for markers of oxidative stress, including malondialdehyde (MDA), and Vitamin C, Lipid profile, blood urea and Serum creatinine. Serum creatinine and estimated glomerular filtration rate (eGFR) were used to assess kidney function.
Results: CKD patients exhibited significantly elevated levels of MDA, indicating increased lipid peroxidation, and a marked decrease in antioxidant enzyme activities compared to controls.
Conclusion: CRF have increased levels of oxidative stress markers and decreased antioxidant levels. The degree of oxidative stress is related to endothelial dysfunction. These factors may be important with respect to the high morbidity and mortality of CVD found in patients with CRF. Using oxidative stress biomarkers in a panel of biomarkers of processes known to impact on CKD development may allow early detection.