STUDY OF EFFECT OF SILDENAFIL CITRATE IN PREGNANT WOMEN WITH OLIGOHYDRAMNIOS

Abstract

Background: About 1 to 2 percent of pregnancies are complicated by oligohydramnios, It puts the fetus at danger by causing iatrogenic premature birth and perinatal morbidity and mortality. The health of the mother and fetus is seriously endangered by oligohydramnios, This study was conducted on the safety andeffectiveness of sildenafil citrate in treating oligohydramnios or borderline oligohydramnios among pregnant woman.
Materials and Methods: 60 pregnant women with oligohydrominos or borderline oligohydramnios participated in a hospital-based prospective case control study at Viswabharathi Medical College and General Hospital. The pregnant women were divided into two groups, each consisting of thirty patients. Group A was allocated to the case group, whereas Group B was associated to the placebo group. The primary amniotic fluid index of the patients was measured when hospitalized. In Group A, 3 liters of isotonic solution (Ringer lactate) were delivered intravenously every 24 hours, along with 50 mg of oral sildenafil citrate every 8 hours and hydration therapy. The control group received a placebo. The amniotic fluid index was re-measured one and two weeks after the intervention among the pregnant woman in both the groups. Drug adverse effects and the maternal pregnancy termination were noted
Results: In both the groups, the amniotic fluid index rose gradually. The Amniotic fluid index was compared between the two groups during the first and second week. No significant increase in the amniotic fluid index is observed in either group over the course of one week. In the second week, the intervention group had a statistically significant increase in amniotic fluid index (7.36 ± 2.86) compared to the control group (6.12 ± 1.36).
Conclusion: our findings indicate that sildenafil citrate consistently increased AFI without causing deleterious embryonic consequences and it is recommended that the incorporation of sildenafil citrate into the treatment of oligohydramnios may be a beneficial approach.