A discussion on Carbapenemase presence in Central Kerala

Abstract

Carbapenem-resistant Enterobacteriaceae (CRE) is a challenge in the ICU as well as
in the Clinical Microbiology laboratory. Carbapenems are best used as reserve drugs
but they are being used in several settings without proper justification. Therefore,
emphasis must be placed on its use after a proper clinical microbiology laboratory
report rationalizing its use. Several simple testing alternatives have come up such as
Rapidec Carba NP. Once CRE is confirmed, carbapenems should be spared and other
options should be chosen such as Ceftazidime/Avibactum alone or with Aztreonam.