A Retrospective Study on 212 Cases of PCOS in a Semi-Urban Subdivisional Hospital to Evaluate the Predictive Value of Prognostic Diagnostic Marker and Its Efficacy in Management

Authors

Anasuya Bhattacharyya, Sudarsan Saha, Biswajit Chakraborty, Prajna Saha, Abhijit Pahari Author

Keywords:

PCOS, LH/FSH ratio, HOMA-IR, Metformin, Diagnostic markers, Retrospective study

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is a multifactorial endocrine
disorder with significant reproductive, metabolic, and psychological implications.
The study aims to assess the predictive value of common diagnostic markers and
their therapeutic efficacy.
Methods: A retrospective review of 212 PCOS cases diagnosed between January
2024 and December 2024 at a semi-urban subdivisional hospital was performed.
LH/FSH ratio, serum testosterone, fasting insulin, HOMA-IR, BMI, and ultrasound
findings were analyzed.
Results: Elevated LH/FSH ratio (>2:1) was seen in 62.2% of patients. Insulin
resistance (HOMA-IR>2.5) was found in 48.5%. Statistically significant correlations
were observed between elevated LH/FSH and oligo/anovulation (p<0.01).
Combination of lifestyle modification and Metformin showed highest clinical
improvement rate (72%).
Conclusion: LH/FSH ratio and HOMA-IR are strong prognostic markers. Early
identification improves therapeutic response and long-term outcomes.