STUDY OF DERANGEMENT OF RENAL PARAMETERS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is a progressive
respiratory condition with systemic manifestations and comorbidities that
significantly impact morbidity and mortality. Among these, renal dysfunction is
increasingly recognized as an important yet underexplored complication.
Objective: To evaluate the prevalence and pattern of renal parameter derangement in
patients with COPD and to assess the correlation between the severity of pulmonary
impairment and renal function.
Methods: This observational cross-sectional study included clinically diagnosed
COPD patients who were evaluated for renal function through serum creatinine,
estimated glomerular filtration rate (eGFR), and blood urea nitrogen (BUN).
Pulmonary function was assessed based on the GOLD (Global Initiative for Chronic
Obstructive Lung Disease) criteria. Statistical analysis was performed to identify
correlations between renal parameters and COPD severity
Results: The mean serum creatinine levels were significantly higher in the COPD
group (1.39 mg/dL) compared to the control group (0.91 mg/dL).The mean eGFR
was significantly lower in the COPD group (62.3 mL/min/1.73 m²) compared to
controls (93.1 mL/min/1.73 m²),. BUN levels were also significantly higher in COPD
patients (24.3 mg/dL) compared to controls (12.3 mg/dL). A significant correlation
was found between reduced eGFR and COPD severity, with higher stages showing
greater reductions in eGFR.
Conclusion: This study demonstrates a significant correlation between COPD
severity and renal dysfunction, with reduced eGFR being more prevalent in advanced
stages of COPD. Abnormal serum creatinine and BUN levels were also observed in
COPD patients compared to healthy controls. These findings emphasize the need for
regular renal monitoring in COPD patients, especially those with advanced disease.